Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl
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چکیده
منابع مشابه
Formulation and evaluation of bilayered gastro retentive floating tablets containing metformin HCl and glipizide
Bilayer tablets of Metformin hydrochloride and Glipizide were formulated. Glipizide is a poor water soluble (BCS class 2) antidiabetic drug. The present study aims to increase the solubility of Glipizide by solid dispersion technique using sodium starch glycolate and crospovidone as super disintegrants. Metformin hydrochloride was formulated by using Hydroxy Propyl Methyl Cellulose as the matri...
متن کاملDesign and In-vitro Evaluation of Sustained Release Floating Tablets of Metformin HCl Based on Effervescence and Swelling
An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...
متن کاملDesign and In-vitro Evaluation of Sustained Release Floating Tablets of Metformin HCl Based on Effervescence and Swelling
An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...
متن کاملFORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF METFORMIN HCl FOR THE TREATMENT OF TYPE-2 DIABETES MELLITUS
Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. ...
متن کاملFormulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M.
The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different formulations (F1-F12) were prepared by direct compression. The results of the physical parameters and assay were found to be within the accept...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2011
ISSN: 1984-8250
DOI: 10.1590/s1984-82502011000300012